Using three different techniques, we first studied the impact of hydrophobic mismatch on an individual level. We addressed the following questions:

      anchorage of transmembrane peptides : the longer the stronger ?

      Asymetric impact on lateral diffusion? "tilting" and "pinching" behaviors

      Conformation of peptides, as determined by IR Spectroscopy ( with F. HOMBLE, Belgium)

      Determination of the critical mismatch for peptide insertion

We then investigated the collective behavior of peptides, controlled by mismatch :

      auto-association of peptides in micro-patches for a critical mismatch

      giant patches (up to 100 µm) and spontaneous formation of vesicles

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